Evidence Synthesis™ at Cornerstone

The Evidence Synthesis team at Cornerstone Research Group provides internationally recognized expertise in systematic review, meta-analysis, indirect comparisons, and network meta-analysis.  We have been involved in network meta-analysis methods, software and guidelines development and the conduct of over 100 systematic reviews, meta-analyses, indirect comparisons, and network meta-analyses.






Our Network Meta-analysis Experience

Cornerstone has in-depth knowledge of developing network meta-analyses to support reimbursement. Cornerstone team members have:

  • Published over 100 scientific publications and text book chapters related to systematic reviews, meta-analysis and network meta-analysis
  • Published meta-analyses in major medical journals including Lancet, JAMA, BMJ, and CMAJ
  • Co-authored the recent PRISMA Network Meta-analysis extension reporting guidelines
  • Co-developed the widely used NetMetaXL software package – downloaded over 10,000 times since Sept 2014
  • Acted as statistical reviewers for major medical journals such as Lancet and PLoS Medicine
  • Served as expert reviewers/advisors to national HTA organizations on network meta-analysis methods
  • Acted as co-investigators on highly competitive academic grants developing advanced methods related to evidence synthesis
  • Taught various courses on systematic reviews and network meta-analysis

Our Team

Dr. Chris Cameron is an experienced health economist/epidemiologist and is the Senior Director of the Evidence Synthesis Group within Cornerstone. Chris has over ten years of experience working or consulting for major health technology assessment organizations including Canadian Agency for Drugs and Technologies in Health (CADTH), CADTH Common Drug Review, pan-Canadian Oncology Drug Review (pCODR), Health Quality Ontario, and Institute for Clinical and Economic Review (ICER) in the United States. Chris is an adjunct professor (scholar) at Dalhousie University  and a co-investigator on a Canadian Institutes for Health Research (CIHR) Drug Safety and Effectiveness Network Team Grant on Network Meta-Analysis, and a statistical reviewer for Lancet and PLoS Medicine.

He has authored over 75 peer-reviewed scientific publications and text book chapters since 2009, some of which have the published in the world’s top medical journals such as Lancet, JAMA, BMJ, Annals of Medicine and CMAJ.  Chris has taught a variety of courses and workshops in North America related to network meta-analysis. Chris is a co-developer of NetMetaXL (www.NetMetaXL.com) which simplifies the conduct and reporting of network meta-analyses. He is also a co-author on the PRISMA extension for network meta-analysis.

Chris holds a BSc in Mathematics, Engineering and Biology (Dalhousie University), and an MSc (Dalhousie University) and a PhD in Epidemiology (University of Ottawa). During his studies, he was awarded Canada’s most prestigious Vanier Canada Graduate Scholarship as well as a Michael Smith Foreign Study Supplement to study at Harvard University. Access to a list of publications can be sought from https://scholar.google.ca/citations?user=IINFVIoAAAAJ&hl=en.

Dr. Brian Hutton is an experienced biostatistician/epidemiologist and is scientific advisor for the Evidence Synthesis Group within Cornerstone. Dr. Hutton holds a Masters’ Degree in applied statistics and a PhD in Clinical Epidemiology (McGill University, 2011).

He is an Associate Scientist with the OHRI’s Clinical Epidemiology Program and an Assistant Professor within the University of Ottawa’s Faculty of Epidemiology and Community Medicine. His primary research interests lie in the realms of systematic reviews, meta-analysis and network meta-analysis, and he is a co-primary investigator of a CIHR-funded knowledge synthesis group which conducts network meta-analysis research projects. Dr. Hutton was a 2013 recipient of a 5-year New Investigator Award from CIHR for his plans to expand applications of network meta-analysis in the area of drug safety. He led the development of the extension of the PRISMA statement for reporting of network meta-analyses, published in 2015, and has taught a variety of workshops in North America related to network meta-analysis. Dr. Hutton also contributes time to the Ottawa Hospital Methods Center and Ottawa Regional Cancer Center in the roles of methodologist and biostatistician.

Dr. Hutton has led courses in systematic reviews in the University of Ottawa’s Faculty of Epidemiology and Community Medicine since 2010, and has also collaborated with the Canadian Agency for Drugs and Technologies in Health as an advisor and external reviewer. Dr. Hutton has an H-index of 31 and has published systematic reviews in a variety of high impact journals including BMJ, the Annals of Internal Medicine, and the Canadian Medical Association Journal. Access to a list of publications can be sought from  https://www.researchgate.net/profile/Brian_Hutton/publications.

Select Evidence Synthesis Publications

1. Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. (2015). The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions: Checklist and Explanations. Ann Intern Med.;162:777-784. doi:10.7326/M14-2385

2. Cameron C, Platt R (2012). New Statistical Methods of Combining Results in Comparative Effectiveness Research. BMJ. 345 :e5798

4. Brown S, Hutton B, Clifford T, Coyle D, Grima D, Wells G, Cameron C (2014). A Microsoft-Excel-based tool for running and critically appraising network meta-analyses-an overview and application of NetMetaXL. Systematic Reviews. 3 (110)

5. Cameron C, Coyle D, Coyle K, Kelly S, Steiner S et al. (2014). Systematic Review and Network Meta-analysis comparing Antithrombotic Agents for the Prevention of Stroke and Major Bleeding in Patients with Atrial Fibrillation. BMJ Open;4:e004301.

6. Castellucci L, Cameron C, Le Gal G, Rodger M, Coyle D, Wells P, Clifford T, Gandara E, Wells G, Carrier M (2014). Clinical and Safety Outcomes of Treatment of Acute Venous Thromboembolism: A Systematic Review and Meta-Analysis. JAMA. 312 (11): 122-1135.

7. Singh J, Cameron C, Noorbaloochi S, Cullis T, Tucker M, Christensen R, Tanjong E, Coyle D, Clifford T, Tugwell P, Wells G (2015). Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis. Lancet. 386 (18): 258–265

8. Castellucci L, Cameron C,  Le Gal G, Rodger M, Coyle D, Wells P, Clifford T, Gandara E, Wells G, Carrier M (2013). Efficacy and safety outcomes of oral anticoagulants and antiplatelet drugs in the secondary prevention of venous thromboembolism: systematic review and network meta-analysis. BMJ. 347:f5133

9. Cameron C, Kelly S, Hsieh S-C, Murphy M, Chen L, Kotb A, Peterson J, Coyle D, Skidmore B, Gomes T, Clifford T, Wells G (2015). Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta-analysis. Headache. 2015;55(S4):221-235

10. McIntosh B, Cameron C, Singh S, Yu C, Dolovich L, and Houldon R. (2012) Choice of therapy in patients with type 2 diabetes inadequately controlled with metformin and a sulphonylurea: a systematic review and mixed-treatment comparison meta-analysis. Open Medicine. 6 (12): E62-E74.

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